Endocrine Abstracts

The insulin-like growth factors together with the IGF receptors, IGFBPs and IGFBP proteases are involved in the regulation of somatic growth and cellular proliferation in vivo and in vitro. Our previous studies demonstrated that overexpression of IGFBP-2 in colon cancer cells (Caco-2) was associated with increased cell proliferation and tumorigenesis. The wild-type Caco-2 cells express and secrete IGFBP-2, IGFBP-4, IGF1R and growth hormone receptors but not IGFBP-3. Therefore,...